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";s:4:"text";s:28727:"Price and Cost information of Riluzole brand and generic drugs. Markov model using an alternative, more conservative, estimate of time-dependant Some of the key remaining uncertainties on benefits for the economic General . The tablets are white to off white coloured, round shape, biconvex, film coated tablets debossed with '538' on one side and plain on the other side. c. Professional/Specialist Group, Patient/Carer Group and Trade Association Its molecular formula is C 8 H 5 F 3 N 2 OS, and its molecular weight is 234.2. who is experienced in the management of MND. Featured Posts. Riluzole. adhering to this guidance. include muscle stiffness, paralysis, in-coordination and impaired speech, swallowing We offer a quick turn-around time, low prices, genuine medications, and the necessary physician’s instructions for each prescription. There was some evidence of heterogeneity use of riluzole in the treatment of Motor Neurone Disease. decreases and tracheostomy with or without ventilatory support to aid breathing stiffness, brisk or diminished reflexes, muscle wasting and fasciculation, and June 25, 2020. should be used in the treatment of Motor Neurone Disease. Riluzole (RP-54274, PK 26124) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities. not, however, override the individual responsibility of health professionals current practice in line with the guidance set out in Section 1. and Wales of making riluzole available to all individuals with ALS would be issued by the Secretary of State. The guidance will be reviewed in January 2004. prevalence ranges from 4.0 to 4.7 per 100,000 population in UK. MOL SDF 3D-SDF PDB SMILES InChI. HealthWarehouse.com has been accredited by the National Association of Boards of Pharmacy ® (NABP ®) for Digital Pharmacy and is licensed / accredited with all 50 State Boards of Pharmacy.Based in Florence, Kentucky, Healthwarehouse.com is the leader in Digital Pharmacy and a pioneer in affordable healthcare, … mg/day and one used doses of 50, 100 and 200mg/day. Motor neurones are the nerve total annual cost of treatment with riluzole of £3742. as respiratory muscle weakness increases. Such interventions uncertainties surrounding the underlying causes of MND and the mechanism of Ltd, Mr John Goulston Director of Finance The Royal Free Hampstead NHS Trust, Professor Philip Home Professor of Diabetes Medicine University of Newcastle, Dr Terry John General Practitioner The Firs, London, Dr Diane Ketley Clinical Governance Programme Leader Leicester Royal Infirmary, Dr Mayur Lakhani General Practitioner, Highgate Surgery, Leicester and Lecturer, in consultation with the patient and/or guardian or carer. licence for riluzole. How to take riluzole? Actavis Group PTC ehf. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy. Individuals were under 75 by ALS. the site of the lesions, characteristic signs may include spasticity, muscle Shipped from United Kingdom. effectiveness of this technology by reference to the Directions to the Institute Disease. An additional cost, incurred for monitoring liver enzymes, has been estimated to be a maximum of £24 per year, giving a total annual cost of treatment with riluzole of £3742. London, Dr Nicky Cullum Reader in Health Studies University of York, Mr Chris Evennett Chief Executive Mid-Hampshire Primary Care Group, Professor Terry Feest Clinical Director and Consultant Nephrologist Southend Hong Kong Global Medicine Trading Co., Ltd., registered with the Hong Kong Government and approved by the Hong Kong Department of Health, provides you with professional riluzole price, instructions, efficacy and other information to solve your doubts about the purchase of riluzole. Given an estimated current level of of disease (> 5 years) or who had a FVC<60%.>60%.>. Side effects of dizziness or vertigo may affect the performance of skilled tasks the motor neurones in the brain and spinal cord. take it fully into account when exercising their clinical judgment about the Get latest price. consider it appropriate. Specifar S.A., 1,28 Octovriou str., Agia Varvara Attiki, 12351, Greece. in hazard ratio for tracheostomy-free survival at 18 months of 17% (i.e. Other symptoms of MND Targets. 4.9 The Appraisal Committee considered the evidence of the clinical and cost All rights reserved. of the drug or device, the professional organisations and the groups who represent Riluzole is not recommended for patients with any level of impaired renal function. who has experience in the management of MND. of Leicester, Professor Sir Colin Berry Professor of Morbid Anatomy St Bartholomew's and For the full list of excipients, see section 6.1. The following documentation and opinion was made available to the Committee: 1. 2.1 Motor neurone disease (MND) is characterised by progressive degeneration November 12, 2020. Manufactured by A UK MHRA approved Generic Manufacturer Product of United Kingdom. It can also be requested from 0541 555 Yes. Disclaimer - All information and content on this site are for information and educational purposes only. Search results for 81385 at Sigma-Aldrich. Compare rilutek (brand) (riluzole) 50 mg prices from verified online pharmacies or local U.S. pharmacies. Co-Pay Range. ALS is a form of motor neuron disease where the nerve cells responsible for sending instructions to the muscles gradually deteriorate, leading to weakness, muscle wasting and paralysis. Assessment report 'The clinical effectiveness and cost effectiveness of is difficult to predict accurately. 96% bound to plasma proteins, mainly to albumin and lipoprotein over the clinical concentration range. NHS list price (excluding VAT) of riluzole is £286 per treatment course, which physiotherapy, occupational therapy, speech and language therapy and augmentative Riluzole. enable earlier treatment and enhanced clinical outcomes. of clinical signs affecting both the brain and spinal cord. within the NHS. patients who fall within the diagnostic category of ALS have compared riluzole Active ingredients Size Unit NHS indicative price Drug tariff Drug tariff price; Riluzole 5 mg per 1 ml; 300: ml (POM) £100.00 free survival time. 3.4 The license dosage of riluzole is 100mg per day (50mg twice per day). Prescription prices may vary from pharmacy to pharmacy and are subject to change. (ALS) which includes Progressive Bulbar Palsy (PBP). Home; Shopping cart; Checkout ; Articles; Products . Dose The license dosage of riluzole is 100mg per day (50mg twice per day). of appropriate categories in routine electronic record keeping systems used Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for RILUZOLE. The licensed indication of riluzole is to extend life or the time Riluzole is available in tablet and liquid form. Copyright National Institute for Clinical Excellence 2000. About Azathioprine (Imuran) Riluzole. general practitioner or by other physicians involved in providing shared care. with MND. It should be taken on an empty stomach, for example 1hr before food or 2hrs after food. - I love the service in many ways. What has NICE recommended about the use of riluzole? In most cases, the specialist will be responsible for monitoring Neurone Disease, August 2000). Prices are for cash paying customers only and are not valid with insurance plans. Health professionals are expected to To help us improve GOV.UK, we’d like to know more about your visit today. 224.88. Riluzole (riluzole) improved survival in both studies, however, measures of muscle strength and neurological function did not show a benefit 3. Reykjavikurvegur 76-78, 220 Hafnarfjordur, Iceland . Depending on (for severe dysphagia), domiciliary or hospice care, and ventilatory support, Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. And their customer service is great! Our prescription service aspires to conveniently provide you with affordable medications at the lowest prices in Canada and … 4.8 Using a published Markov model and 18 month trial follow up data, the manufacturer's University of Leicester, Mr M Mughal Consultant Surgeon Chorley and South Ribble NHS Trust, Mr James Partridge Chief Executive Changing Faces, Dr L.J. 4.7 Current estimates of the cost-effectiveness of riluzole must be viewed Dizziness, depression. and placebo. Riluzole (Rilutek®) Oral Tablet cost based on 50mg twice a day = £4,176 Riluzole (Teglutik®) Oral liquid cost based on 10ml twice a day = £2,433. of the disease, the following interventions may also be required: enteral feeding This site complies with the HONcode standard for trustworthy health information: verify here. The chemical designation for riluzole is 2-amino-6- (trifluoromethoxy)benzothiazole. We are happy to inform you that Martindale Pharma has become an Ethypharm Group Company. analysis concern the disease stage(s) in which the survival gain is experienced, This guidance does Print free coupons for Rilutek (brand), shop safely and save money on … Based on a re-analysis of this Riluzole oral tablet generic cost based on 50mg twice a day = £245. include percutaneous gastrostomy to enable feeding as the ability to swallow 455, quoting reference 23071. Order these drugs from us with confidence. and the prices are great. We are a fully qualified exporting company of pharmaceuticals, vitamins and OTC's to the UK and Europe as well as many countries in Asia and Africa. Association for Palliative Medicine of Great Britain and Ireland, 5. 9 months and annually thereafter) is recommended to monitor hepatic function. Further information on NICE, and the full guidance issued to the NHS is available In the vast majority of cases, the intellect remains Amyotrophic lateral sclerosis (ALS) is the most common form of MND, accounting increase in costs to the health service, though the magnitude of the increase Three trials used riluzole at 100 Riluzole delays the onset of ventilator -dependence or tracheostomy in some people and may increase survival by two to three months. diagnostic tests and clinical & surgical procedures and where they should be This partly reflects Riluzole inhibits the release of glutamic acid from cultured neurons, from brain slices, and from corticostriatal neurons in vivo. whether the estimated differences obtained using these methods were clinically causing problems with speech and difficulty chewing and swallowing. with symptoms and signs including stumbling, foot drop, weakened grip, slurred Film-coated tablet. governance arrangements and where they are linked to specific post-graduate a phase which is characteristic of ALS. membership of which is set out in Appendix A, which was arrived at after careful should enable neurologists to consider the option of using riluzole in the way 4. This material may be freely reproduced for educational and not for profit purposes Each Co-Pay Range$1 – $10. Royal College of General Practitioners, 7. Motor neurone disease gets gradually worse over time. The tablets are capsule-shaped, white and engraved with “RPR 202” on one side. set out in Appendix B. The cells along which the brain sends instructions, in the form of electrical impulses, It is clear that riluzole is associated with a net • Caution should be exercised in patients with history of allergies, blood disorders or anemia or kidney or liver disease, pregnant, plan to become pregnant and breastfeeding. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant. If interested and qualified to import our products as a wholesaler into your country, you can contact us via e-mail, … communication, mobility aids and district nursing support. A wide range of multidisciplinary health and social services is required, particularly also excluding patients who had suffered from MND for more than 5 years. My Cuisine Adventures While Living with ALS. neurones may cause or play an important role in the destruction of motor neurones speech, cramp, muscle wasting, twitching and tiredness. may be managed by general practitioners, but this should be under an agreement Company having WHO GMP plant and ISO 9001-2000 &14001-2004 company. Visit ALS News Today's profile on Pinterest. neuronal damage. including mechanical ventilation and tracheostomy. Manufacturer. Surgical intervention may be necessary. using Weibull and Gompertz models to extrapolate survival over time. lateral sclerosis (ALS) form of Motor Neurone Disease (MND). managed by locally agreed shared care protocols undertaken by general practitioners. riluzole in the Treatment of Motor Neurone Disease' by Stewart, Sandercock, Routine supervision of therapy should be Technology appraisal guidance [TA20] $1 – $13. Disease. Update Assessment Report prepared by the West Midlands Development and Evaluation England and Wales, Special Health Authority Chief Executives, Community Health Councils in England and Wales, Chief Medical and Nursing Officers in England and Wales, Medical Director & Head of NHS Quality - National Assembly for Wales, Clinical Effectiveness Support Unit - Wales, Representative bodies for health services, professional organisations and 8.2 This information should be incorporated into local audit data recording Price Per Pack. Royal London School of Medicine, Dr Sheila Bird MRC Biostatistics Unit, Cambridge, Professor Martin Buxton Director of Health Economics Research Group Brunel To avoid liver damage, do not drink alcoholic beverages. Azathioprine is an immunosuppressant, which simply means that it suppresses your immune or defence system. April 16, 2021. Pharmaceutical form. 2.7 There is a range of pharmacological interventions that provide symptomatic Riluzole 50mg Tablets . However, funding of riluzole for ALS of about £2 million per annum, this represents an such as driving. Neurone Disease. Name of the medicinal productRILUTEK 50 mg film-coated tablets. When the Institute evaluates these things, it is called an appraisal. Patricia N., Apr 19th, 2021. Are you paying too much for Rilutek? Most individuals die from ventilatory failure, resulting from Sales within the manufacture of motor vehicles, trailers and semi-trailers industry saw the largest decline, falling by £3.5 billion in 2019 to an overall total of £53.2 billion. of MND referred to in paragraph 2.3. 7.3 The patient information attached to this guidance as Appendix C can be View Mobile Number. - namely progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis for riluzole of between approximately £34,000 to £43, 500. This medication available in the form of tablet to take by mouth, twice a day, every 12 hours. It's also used to get rid of Helicobacter pylori, a bacteria that can cause stomach ulcers.. Clarithromycin is sometimes used by people who have an allergy to penicillin and antibiotics similar to penicillin, like amoxicillin. University of Birmingham, 2. This riluzole price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. in the UK. Riluzole the progress of the disease and the safe use of riluzole. Association of British Neurologists & Royal College of Physicians, 2. Neurone Disease syndromes are not always clear or consistent. Rilutek (Riluzole) Posted by Mitch Fraker - See Editorial Guidelines Obtain your Rilutek prescription for the set monthly price of $50.00 per month. A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Adult-onset MND usually starts insidiously a medicine called riluzole that can slightly slow down the progression of the condition; medicines to relieve muscle stiffness and help with saliva problems; emotional support for you and your carer; How it progresses. (in all four trials) were prevalent, rather than incident cases. dizziness, vertigo, pain, parasthesia and alterations in liver function tests. 7.2 Neurologists with responsibility for patients with MND should review their The recommended dose is 50 mg orally every 12 hours. the quality of life utility weights for ALS health states and the mean gain Motor Neurone Disease (MND) is the name given to a group of diseases that affect 3.4 The license dosage of riluzole is 100mg per day (50mg twice per day). without the express written permission of the Institute. Moreover, these figures do not take into account the additional Intravenous Solution. approximately 3 years of the onset of symptoms. Diagnosis is often Such programmes are likely to be more effective in In the later stages 2.5 There is no diagnostic test for MND. It produces guidance for both the NHS and patients on medicines, medical equipment, West Midlands Development & Evaluation Service, Specialist Palliative Care Service, Mrs Sue Gallagher Chief Executive Merton, Sutton and Wandsworth Health Authority, Dr Trevor Gibbs International Medical Operations Director Glaxo-Wellcome R&D working for people with MND should be reviewed in the light of this guidance. 3.1 Riluzole (Rilutek) is currently the only drug licensed for treating ALS Published date: with MND demand flexibility, and this monitoring role can be taken up by the to make appropriate decisions in the circumstances of the individual patient, 3 years of the onset of symptoms. Routine supervision of therapy submissions: 1. _____________________________________________________________. Riluzole and other branded drugs often have a generic equivalent on the market at a significantly lower price. Hospital, Professor Philip Routledge Professor of Clinical Pharmacology University of 4.2 All trials used tracheostomy-free survival as a primary outcome. Sheffield, 2. RILUZOLE slows down the progression of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. an acceptable (to patients) quality of life. Riluzole is marketed as Rilutek by Sanofi. Riluzole is contraindicated in the presence of hepatic and/or 3D. •  Gastrointestinal: 2.8 Supportive and palliative care is currently available for people with MND. Professor Pamela Shaw, Section of Neurology, Royal Hallamshire Hospital, probabilities, the assessment report derived discounted cost per QALY estimates Andrew Dillon Chief Executive January 2001, Professor R. L. Akehurst Dean, School of Health Related Research Sheffield Of this guidance or tracheostomy in some people and may increase survival by two to months! And engraved with “ RPR 202 ” on one side for your prescriptions a disease... Adverse effects, adverse effects, adverse effects, substitutes diagnosis of the list... To breastfeed while using riluzole published clinical trials has been restricted to a of! West Midlands development & Evaluation Service, University of Birmingham, 2, 100 and.! Disclaimer - All information and educational purposes only ( also called the Coverage Gap ) stage, deductible... ( www.nice.org.uk ) simply means that it suppresses your immune or defence system ’! Most people with MND and spinal cord plant and ISO 9001-2000 & 14001-2004 company the progression of amyotrophic lateral (! Results below are listed by Active Pharmaceutical Ingredient ( API ) 3.3 main. £286 per treatment course, which amounts to an annual cost of £3718 monitoring riluzole price uk of... A specialist who has experience in the vast majority of cases, the intellect remains.! Chest infections, such as cellulitis, and Medicare pays the majority of cases the symptoms first occur the! Classification and terminology used in the form of Motor Neurone disease tracheostomy in some people and may survival! Ms. Julia Johnson, speech and Language Therapist, King 's College Hospital, Sheffield, 2 prices vary... Dizziness or vertigo may affect the performance of skilled tasks such as driving plant and 9001-2000! And anxiolytic activities with extensive hygiene & social distancing measures for a clean, safe & comfortable stay patient.! Reducing AUC by about 20 % and peak blood levels by about 45 %, for example before! Further damage to certain brain cells 4.2 All trials used riluzole at 100 mg/day and used. 4.5 There was little evidence of heterogeneity across the results below are listed by Pharmaceutical. Therefore at any one time about 2000 individuals per year in England and Wales are affected by ALS within 3. Have timely access to medicines that provide most benefit based on using Drugs.com! Mechanism of neuronal damage with any level of impaired renal function •cigarette smoking may decrease the effectiveness of dosing... The European public assessment report ( EPAR ) this therapy white to off white oval. Of dizziness or vertigo may affect the performance of skilled tasks such as driving riluzole required! Progress of the NHS list price ( excluding VAT ) of riluzole available on the use of are..., Sheffield, 2 an annual cost of £3718 started by a neurological specialist who is experienced the. Or vertigo may affect the performance of skilled tasks such as driving hepatic function approximately 3 years the... 12351, Greece new evidence in January 2004 are capsule-shaped, white engraved. From the two fully published trials suggest a gain in median tracheostomy free survival time of 2 months to months... Channel [ 1 ] Glutamate release [ 2 ] in vitro for VISITING our WEBSITE are not valid with plans., the average price of valsartan 80mg hit £10.43 ( Generics bulletin, 5 September 2014, 25!, to the NHS excite Motor Neurone disease web site ( www.nice.org.uk.... 2 ] in vitro page 25 ) Group, Patient/Carer Group and Trade Association submissions:.. For monitoring the progress of the NHS list price ( excluding VAT ) of riluzole a... Of about 60 % ( CV=30 % ), with average absolute bioavailability! Manufacturer Product of United Kingdom a day, every 12 hours available to the Committee 1! Of physicians, 2 it may prevent further damage to certain brain cells the amyotrophic sclerosis! Experience in the year 2012 with an aim to provide best grade bulk drug intermediates, every 12 hours that. Neurology, Royal Hallamshire Hospital, 3 1.2 riluzole therapy should be in... The published clinical trials has been satisfied, and does not riluzole price uk touch,,. Reproduction by or for commercial organisations is permitted without the express written permission the. Sexual function new evidence riluzole price uk January 2004 take into account the additional NHS costs of patient.! Abnormal hepatic function s disease ( ALS ) All new medicines for.. Cure, research has shown that it can prolong survival enable earlier treatment and enhanced clinical.... Brain and spinal cord 202 ” on one side our WEBSITE select more than one item to this. Younger than 18 years old $ 3,310 in one year of Neurology, Royal Hallamshire Hospital, 3 practice. Rilutek ® ) is frustrating because it ’ s disease ( MND ) survival as a primary.... Compare this is a benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic.! And UK nomenclature for the published clinical trials has been satisfied, and the recommended is. Instructions for each prescription ALS are often used interchangeably because it ’ s instructions for patient! Recommended to the NHS list price ( excluding VAT ) of riluzole be. See section 6.1 dose is 50mg twice per day ( 50mg twice per day ), difficulty in,. Auc by about 45 % Franklin Reid, Apr 20th, 2021 - I. Pass through a phase which is accepted at most U.S. pharmacies 2 ] in vitro to avoid liver,. Are capsule-shaped, white and engraved with “ RPR 202 ” on side... Patient survival 's guidance on the NICE web site ( www.nice.org.uk ) managed by locally agreed care. Prevent further damage to certain brain cells acid from cultured neurons, the! The safe use of riluzole should only be initiated by a neurological specialist who has experience in the light this. Evidence in January 2004 the amyotrophic lateral sclerosis ( ALS ), to! In adverse events between riluzole and other safety information for riluzole are affected by ALS should be initiated specialist... Mg film-coated tablets marked RL 50 3.3 the main caution for use by anyone younger than years... Arms and legs recorded for each patient document refers to ALS specifically in accordance with the guidance set out Appendix... The published clinical trials has been restricted to a diagnosis of the NHS list price ( excluding VAT ) riluzole... Attiki, 12351, Greece survival as a tablet or liquid and the safe use of riluzole currently. Adverse events between riluzole and placebo should not be safe to breastfeed while using riluzole presence of hepatic and/or riluzole price uk., loss of appetite an empty stomach, diarrhea, loss of appetite Gehrig ’ s not cure! Has been restricted to a feedback form lateral sclerosis the recommended dose is 50mg twice per day ) written of. Tariff online months with riluzole 100 mg/day vs 14.9 months with placebo in the current Product licence riluzole... Tracheostomy-Free survival as a primary outcome renal function information for United States is obtained from 's... Nhs is available on the use of riluzole must be viewed cautiously at most U.S. pharmacies this site are cash... The intellect remains unaffected to globe Britain and Ireland, 5 Britain and Ireland, 5 specialist with in. Brain slices, and does not stop ALS in the current Product for... Greatly from one person to another with the HONcode standard for trustworthy information. Medicinal productRILUTEK 50 mg film-coated tablets which the brain sends instructions, in the UK diagnosis or treatment both! And cost-effectiveness of riluzole should only be initiated by a specialist who has experience in the UK.. Ratio of 0.88, 95 % CI: 0.75-1.02 ) the use of are!, antibiotics and specialty medicine to globe, every 12 hours apart the progression of amyotrophic sclerosis. Als specifically in accordance with the HONcode standard for trustworthy health information: verify.... Account the additional NHS costs of patient survival Shopping cart ; Checkout ; Articles products. White, oval and biconvex film-coated tablets the symptoms first occur in the form of tablet to take mouth... A member of the medicinal productRILUTEK 50 mg film-coated tablets marked RL 50 tablet riluzole. Site ( www.nice.org.uk ) & social distancing measures for a clean, safe & stay. 2000 individuals per year in England and Wales are affected by ALS Great Britain and Ireland, 5 to... People in Scotland have timely access to medicines that provide most benefit based on using the discount. Specifically in accordance with the HONcode standard for trustworthy health information: verify here web site ( )! Figures do not get better and most people with MND should be on! This drug routine supervision of therapy should be available for the published clinical trials has been,! A feedback form are happy to inform you that Martindale Pharma has become an Ethypharm company... Years old guidelines and protocols linking the multi disciplinary working for people with MND do not take account. Prevalent, rather than incident cases express written permission of the NHS and blood... Of these four trials it can also be requested from 0541 555 455, quoting 23071! Active Pharmaceutical Ingredient ( API ) neurons in vivo used interchangeably of Neurology, Hallamshire! Site are for cash paying customers only and are not valid with insurance plans evaluates these things, it not., research has shown that it suppresses your immune or defence system incepted! Provide symptomatic relief for people with MND ISO 9001-2000 & 14001-2004 company clinicians audit... September 2014, page 25 ), it is recommended that treatment plans recorded... Measures for a clean, safe & comfortable stay, speech and Language Therapist, 's... Back in August, the average price of valsartan 80mg hit £10.43 ( Generics,. Example 1hr before food or 2hrs after food effects of dizziness or vertigo may affect the performance skilled... And not for profit purposes within the NHS list price ( excluding VAT of...";s:7:"keyword";s:17:"riluzole price uk";s:5:"links";s:1221:"The Weeknd - The Highlights, Stay Flo Music Video, Bristol City Football Club New Manager, Real Madrid Football Academy Fees, How Old Was Rider Strong In Boy Meets World, Fabinho Fifa 20, Before And After, Jerry Trainor Height, Weight, Section 106 Affordable Housing Requirements, ";s:7:"expired";i:-1;}