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A positive outcome in this Phase 3 trial could lead to inclusion of ZADAXIN in the China Sepsis Treatment Guidelines. This will be followed by a dose-confirmation phase, including a specific population of NSCLC patients. The high numbers and density of the future human population will result in more regular pandemic outbreaks that spread faster and are harder to cure. All forward-looking statements are based on information currently available to SciClone and SciClone assumes no obligation to update any such forward-looking statements. April 17, 2018. We are not responsible for the content or availability of linked sites. Statistical Analysis of Prothena’s VITAL Phase III Study, Nephrologist Survey for ZS-9 in Hyperkalemia, Physician Survey on Community-Acquired Bacterial Pneumonia, Physician Survey on the Opportunity for LJPC-501, WordPress Download Manager - Best Download Management Plugin. In vitro studies have demonstrated synergistic activity using different cell lines, including non-small cell lung cancer. FOSTER CITY, Calif., Sept. 26, 2016 /PRNewswire/ -- SciClone Pharmaceuticals, Inc. (NASDAQ: SCLN) today announced two important achievements in advancing the Company's clinical pipeline and development portfolio in Greater China. The dose-escalation portion of the trial, which is expected to complete enrollment in early 2017, includes subjects with current solid tumors treated initially with 50 mg/m2. One example of their products includes ZADAXIN, SciClone's lead product, which can be used for treating HBV (hepatitis B), HCV (hepatitis C), certain Representing nearly 30-40 per cent of the global population, this combined demographic will represent a significant strain on the health systems of developed nations. All forward-looking statements are based on information currently available to SciClone and SciClone assumes no obligation to update any such forward-looking statements. SciClone Pharmaceuticals is a revenue-generating, specialty pharmaceutical company with a substantial commercial business in China and a product portfolio spanning major therapeutic markets including oncology, infectious diseases and cardiovascular disorders. PT-112 also provides us with the opportunity to leverage the Class 1 regulatory pathway, offering the potential for local manufacturing and other advantages that could accelerate development and registration in China. View SciClone Pharmaceuticals , Inc. (www.sciclone.com) location in California, United States , revenue, industry and description. The sepsis trial is a major component of SciClone's strategy to grow ZADAXIN sales in the indications for which it is approved, as well as new indications. Try D&B Hoovers Free LifeSci Capital is not responsible for the content of linked third party websites. SciClone's proprietary lead product, ZADAXIN® (thymalfasin), is approved in over 30 countries and may be used for the treatment of hepatitis B (HBV), hepatitis C (HCV), and certain cancers, and as an immune system enhancer, according to the local regulatory approvals. The primary end point is the 28-day mortality rate, with secondary endpoints, including measurement of immunomodulatory parameters. September 10, 2010. In October 2017, SciClone was taken private by a consortium of Chinese investors led by GL Capital for some $605 million. *The eventual widespread adoption of artificial intelligence (AI) and quantum computing within the pharmaceutical industry will lead to new, AI-assisted discoveries of drugs and treatments to cure a range of medical conditions. These statements are subject to risks and uncertainties that are difficult to predict and actual outcomes may differ materially. Sepsis in China represents a major unmet medical need, affecting more than four million patients and with a mortality rate over 20%. To access the full research report, please click on the link below. Given the poor prognosis of patients with refractory and/or recurrent platinum-resistant advanced cancer, the opportunity to develop a treatment for patients in Greater China with a therapeutic agent that combines tolerability with mechanistic differentiation is highly desirable. This will be followed by a dose-confirmation phase, including a specific population of NSCLC patients. Find related and similar companies as … Results thus far have shown tolerability, pharmacokinetic stability and signals of clinical benefit and biological activity with no overlapping toxicities when compared with docetaxel. SciClone maintains a pipeline of products that it is shepherding through the approval process in China; therapeutic areas of focus include oncology, infectious disease, and cardiovascular disorders. Therapeutic focus - Sutent liver cancer failure leaves thin late-stage pipeline. The goal of the SciClone-sponsored Phase 3 trial in sepsis is to build on positive data from a smaller, previously conducted trial which showed a survival advantage for sepsis patients treated with ZADAXIN. We use cookies on this website. As we have noted previously, we are hopeful that with a positive outcome in the Phase 3 trial, ZADAXIN could be actively recommended in the China Sepsis Treatment guideline for sepsis treatment, potentially expanding utilization and continuing ZADAXIN's strong growth momentum. Friedhelm Blobel, PhD, SciClone's President and Chief Executive Officer, commented: "In different ways, both of these clinical development programs represent essential strategies to ensure SciClone's continued growth over the near and long term. We believe that it continues to have significant growth potential, and our sepsis initiative will be key to expanding its market leadership. Please also refer to other risks and uncertainties described in SciClone's filings with the SEC. ", Phase 3 Trial in Sepsis Has Potential to Expand ZADAXIN Market Leadership. These treatments will be provided annually and over time will become affordable to the masses, resulting in longer average human lifespans and a new windfall for the pharmaceutical industry.
*By 2050, the world population will rise above nine billion, over 80 percent of whom will live in cities. The recently initiated Phase 1 study of PT-112 is being conducted in Taiwan. SciClone Pharmaceuticals, Inc. was organized in 1990 as a California corporation and reincorporated in Delaware in 2003. Logo - http://photos.prnewswire.com/prnh/20150722/240358LOGO, 1350 Avenue of the Americas, 23rd FloorNew York, NY 10019, http://photos.prnewswire.com/prnh/20150722/240358LOGO. FOSTER CITY, Calif., Sept. 26, 2016 /PRNewswire/ -- SciClone Pharmaceuticals, Inc. (NASDAQ: SCLN) today announced two important achievements in advancing the Company's clinical pipeline and development portfolio in Greater China. These treatments will be provided annually and over time will become affordable to the masses, resulting in longer average human lifespans and a new windfall for the pharmaceutical industry. SciClone anticipates completing enrollment in the Phase 3 trial in 2018, with data potentially available in 2019. By using this site, you agree that we may store and access cookies on your device. It was rationally designed to solve issues of toxicity while providing enhanced therapeutic benefit and minimizing dependency on DNA repair-based drug resistance historically associated with the therapeutic class. In addition, manufacturing of PT-112 has been initiated in China and is expected to be ready in time for submission of an Investigational New Drug (IND) application in China in 2017. Our corporate headquarters are located in San Mateo, California. Are the stars waning for Pfizer’s haemophilia A gene therapy. PT-112 also provides us with the opportunity to leverage the Class 1 regulatory pathway, offering the potential for local manufacturing and other advantages that could accelerate development and registration in China. The Phase 3 trial is designed to generate data confirmatory of ZADAXIN's effectiveness in treating sepsis. As we have noted previously, we are hopeful that with a positive outcome in the Phase 3 trial, ZADAXIN could be actively recommended in the China Sepsis Treatment guideline for sepsis treatment, potentially expanding utilization and continuing ZADAXIN's strong growth momentum. We are not an agent for these third parties nor do we endorse or guarantee their products. The adverse effects of this class of chemotherapeutics, including renal and neurotoxicity, have limited their use. EpicentRx Inc. ("EpicentRx"), a San Diego-based clinical cancer immunotherapy company and SciClone Pharmaceuticals International Ltd., ("SciClone") today … In addition, DC Bead for liver cancer patients was launched in 2015 and efforts are underway to educate physicians on this product. PT-112 is a novel chemical entity and represents a potential first-in-class platinum-containing compound. A positive outcome in this Phase 3 trial could lead to inclusion of ZADAXIN in the China Sepsis Treatment Guidelines. We use cookies on this website. Their product line revolves around major therapeutic markets, such as oncology, infectious diseases, and cardiovascular disorders. The first patient has been treated in the Phase 3 trial of ZADAXIN® in sepsis, a life-threatening infectious disease in which the drug has previously demonstrated therapeutic benefit in a Phase 2 clinical trial. You are now leaving LifeSci Capital's website and are going to a website that operated by a third party.
Belonging to the pharmaceuticals sector means this company will be affected directly and indirectly by a number of disruptive opportunities and challenges over the coming decades. In vitro studies have demonstrated synergistic activity using different cell lines, including non-small cell lung cancer.
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