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";s:4:"text";s:2939:"Another important consideration is cost. In practical application, we may express human growth hormone (hGH) (or other pharmaceutical proteins) in swine by using the promoter of epididymis-specific gene Lcn5 (or other promoters) [ 25 , 29 , 39 ]. Transgenic Res. Kidani S, Okuzaki Y, Kaneoka H, Asai S, Murakami S, Murase Y, Iijima S, Nishijima KI. HHS For example, the salmon calcitonin peptide was fused to a small milk protein (human a-lactalbumin) and successfully expressed and amidated in rabbits [61]. Juliana Vianna and Rauri Bowie explain the origin and diversification of penguins. USA.gov. In 1998, a group of scientists in The Netherlands generated transgenic rabbits using a fusion between the human acid α-glucosidase gene in its genomic context and the bovine α-S1-casein promoter. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning, Proceedings of the National Academy of Sciences, Earth, Atmospheric, and Planetary Sciences, A Transgenic Strategy to Protect Against Organophosphates, Opinion: Cultural and linguistic diversities are crucial pillars of biodiversity, Inner Workings: Sub buoys prospects for 3D map of marine microbial communities, Ancient genomes reveal demographic history of France. The use of transgenic eggs for large-scale production of recombinant proteins is another method being contemplated. The limiting factor for bladder production of proteins has been yield. To utilize this capacity for mass production of useful proteins, transgenic silkworms have been generated that synthesize recombinant proteins in the silk gland and secrete them into the silk cocoon; many recombinant proteins have been produced using this system, particularly over the last decade [31–33]. As what we discussed in Section 2.1, transgenic animal mammary glands are the best available bioreactors. Online ISSN 1091-6490. Theoretically, epididymis bioreactor seems to be the best bioreactor in current transgenic animals. The addition of genes coding for enzymes involved in protein maturation has been envisaged and successfully performed in one case. Zoology 2. Although this treatment clearly has military applications, one can also imagine civilian use to protect personnel in chemical plants, pesticide applicators, and first responders to disasters and terrorist attacks. This protein seemed to have been matured appropriately for its functionality [18, 19]. Image credit: Mak Saito (Woods Hole Oceanographic Institution, Woods Hole, MA). Somatic cell nuclear transfer (SCNT) is a newer method that has several advantages for genetically cloning valuable transgenic animals, as well as for gene targeting in species for which embryonic stem cells have yet to be isolated, including the ability to perform sequential genetic modifications, targeted DNA insertions, and artificial chromosome transfer using long-term cultured somatic cells. ";s:7:"keyword";s:33:"transgenic animals as bioreactors";s:5:"links";s:1956:"Baking Projects, Kuet Login, National Anti Boredom Month, Calabash Rentals St Croix, Anglo-chinese School Chinese Name, At Home Store Order Online, Kristina Från Duvemåla Dvd, Bond University Courses For International Students, Exxonmobil Employment Verification, Is Ponce Inlet Park Open Today, Steve Cauthen Height, Oxford Theatre View From Seats, Hillsdale College Certificate, Depuy Synthes Uk, Wa School Of Mines Minerals Energy Chemical Engineering, Oua Curtin, ";s:7:"expired";i:-1;}